This study found that narrowband UVB light therapy reduced the severity score of atopic dermatitis, a common inflammatory skin disease, by at least 50% for all subjects. The study then looked at the mechanisms of action and found that UVB light therapy suppressed inflammatory Th2 and T22 immune cells and normalized expression of skin barrier proteins to reduce skin thickening due to overactive keratinocytes.
Skin
Reversal of Atopic Dermatitis with Narrow-Band UVB Phototherapy and Biomarkers for Therapeutic Response
Journal of Allergy and Clinical Immunology
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Skin
Phototherapy in Psoriasis: A Review of Mechanisms of Action
Journal of Cutaneous Medicine and Surgery
This review provides an summary of the mechanisms thought to be responsible for the therapeutic effects of phototherapy for psoriasis. These mechanisms include through the alteration of the cytokine profile to shift immune response away from inflammatory pathways, through the induction of apoptosis of cells found in psoriasis lesions, and through the promotion of immunosuppression.
Skin
Phototherapy in Psoriasis: A Review of Mechanisms of Action
Journal of Cutaneous Medicine and Surgery
This review provides an summary of the mechanisms thought to be responsible for the therapeutic effects of phototherapy for psoriasis. These mechanisms include through the alteration of the cytokine profile to shift immune response away from inflammatory pathways, through the induction of apoptosis of cells found in psoriasis lesions, and through the promotion of immunosuppression.
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Narrow Band Ultraviolet B Versus Red Light-Emitting Diodes in the Treatment of Facial Acne Vulgaris
Photobiomodulation, Photomedicine, and Laser Surgery
This randomized controlled trial compared narrowband UVB light therapy and red light therapy, each used in combination with 2% erythromycin cream, for the treatment of acne. They found that narrowband UVB therapy demonstrated greater efficacy than red light therapy in reducing acne lesion counts and improving overall acne severity.
Skin
Narrow Band Ultraviolet B Versus Red Light-Emitting Diodes in the Treatment of Facial Acne Vulgaris
Photobiomodulation, Photomedicine, and Laser Surgery
This randomized controlled trial compared narrowband UVB light therapy and red light therapy, each used in combination with 2% erythromycin cream, for the treatment of acne. They found that narrowband UVB therapy demonstrated greater efficacy than red light therapy in reducing acne lesion counts and improving overall acne severity.
Skin
Comparison of efficacy of narrow band ultraviolet b phototherapy with emollients in uremic pruritus patients at tertiary care hospital
The Professional Medical Journal
Pruritus, severe itching of the skin, is a common, irritating symptom associated with chronic kidney disease. This study compared the use of narrowband UV light therapy to the use of medical moisturizers in hemodialysis patients and found that UVB light therapy was more effective at lowering itch score in this patient population. The UVB treatment group saw a statistically reduction of itch-score of more than half from baseline levels.
Skin
Comparison of efficacy of narrow band ultraviolet b phototherapy with emollients in uremic pruritus patients at tertiary care hospital
The Professional Medical Journal
Pruritus, severe itching of the skin, is a common, irritating symptom associated with chronic kidney disease. This study compared the use of narrowband UV light therapy to the use of medical moisturizers in hemodialysis patients and found that UVB light therapy was more effective at lowering itch score in this patient population. The UVB treatment group saw a statistically reduction of itch-score of more than half from baseline levels.