Several large population studies, such as Avoidance of sun exposure as a risk factor for major causes of death and Higher ultraviolet light exposure is associated with lower mortality, have shown that greater exposure to sunlight is linked to lower mortality and longer life expectancy. Although this has often been attributed to vitamin D, supplementation studies have not consistently shown the same benefits, suggesting that vitamin D explains only part of the effect.
The resulting publication from a 2024 expert review, Beneficial health effects of ultraviolet radiation: expert review and conference report, brought together clinical and biological research to show that UVB exposure influences multiple systems in the body - including cardiovascular, immune, metabolic, and neuroendocrine pathways - through mechanisms that extend beyond vitamin D.
Mechanistic studies help explain how this works. Photo-neuro-immuno-endocrinology: How the ultraviolet radiation regulates the body, brain, and immune system describes how UVB exposure activates a broad range of hormones, neurohormones, neurotransmitters, and immune mediators - including serotonin, dopamine-related peptides, and anti-inflammatory compounds. These signals can affect mood, stress regulation, energy balance, and immune function.
Similarly, How UV Light Touches the Brain and Endocrine System Through Skin, and Why shows that UVB can initiate communication between the skin and the brain through vitamin D-independent pathways. This includes the production of signaling molecules such as beta-endorphin and other peptides that influence stress responses, behavior, and hormonal activity.
Research from the University of British Columbia demonstrates that UVB also impacts the gut. Their study The gut-skin axis: a bi-directional, microbiota-driven relationship with therapeutic potential shows that UVB can alter gut-related immune and metabolic processes, partly through interactions with the microbiome, helping regulate inflammation and barrier function.
In addition, Impact of ultraviolet radiation on cardiovascular and metabolic disorders: The role of nitric oxide and vitamin D highlights that UV exposure can increase nitric oxide levels in the body, which helps relax blood vessels, improve circulation, and potentially reduce cardiovascular risk - again, independently of vitamin D.
Overall, this body of research indicates that UVB exposure acts as a broad regulator of human physiology, influencing multiple interconnected systems beyond its role in vitamin D production.

