A meta-analysis of randomized clinical trials found that vitamin D intakes of 700–800 IU per day reduced the relative risk of hip fracture by 26% and any nonvertebral fracture by 23% compared with just calcium or placebo. No significant benefit was observed in randomized trials with intakes of 400 IU vitamin D per day.
Bones
Fracture Prevention With Vitamin D Supplementation
JAMA
Related Studies
Bones
The Effect of Latitude on the Risk and Seasonal Variation in Hip Fracture in Sweden
Journal of Bone and Mineral Research
This study found that hip fracture incidence in Sweden increased by 3.0% per degree increase in latitude for men and by 1.9% for women. There was a marked seasonal variation of hip fracture with the highest risk in February and lower by 37.5% in men and by 23.5% women during the summer. The associations found with latitude and season are consistent with a role of vitamin D in hip fracture causation.
Bones
The Effect of Latitude on the Risk and Seasonal Variation in Hip Fracture in Sweden
Journal of Bone and Mineral Research
This study found that hip fracture incidence in Sweden increased by 3.0% per degree increase in latitude for men and by 1.9% for women. There was a marked seasonal variation of hip fracture with the highest risk in February and lower by 37.5% in men and by 23.5% women during the summer. The associations found with latitude and season are consistent with a role of vitamin D in hip fracture causation.
Bones
The serum 25-hydroxyvitamin D levels and hip fracture risk: a meta-analysis of prospective cohort studies
Oncotarget
In this study, the relative risk of low 25(OH)D levels show a statistically significant 58% increase in hip fracture risk. Subgroup meta-analysis across different genders, ages, locations, study types, and follow-up durations confirmed that low serum 25(OH)D levels significantly increase hip fracture risk, especially when below 24 ng/mL.
Bones
The serum 25-hydroxyvitamin D levels and hip fracture risk: a meta-analysis of prospective cohort studies
Oncotarget
In this study, the relative risk of low 25(OH)D levels show a statistically significant 58% increase in hip fracture risk. Subgroup meta-analysis across different genders, ages, locations, study types, and follow-up durations confirmed that low serum 25(OH)D levels significantly increase hip fracture risk, especially when below 24 ng/mL.
Bones
Bone Mineralization Defects and Vitamin D Deficiency: Histomorphometric Analysis of Iliac Crest Bone Biopsies and Circulating 25-Hydroxyvitamin D in 675 Patients
Journal of Bone and Mineral Research
This study of 675 healthy adults who died prematurely due to accidents found no evidence of osteomalacia present in bone biopsies when circulating concentrations of 25(OH)D were at least30 ng/mL. They found that 22% of the adults with a circulating concentration of 25(OH) D of between 21 and 29 ng/mL had evidence of osteomalacia.
Bones
Bone Mineralization Defects and Vitamin D Deficiency: Histomorphometric Analysis of Iliac Crest Bone Biopsies and Circulating 25-Hydroxyvitamin D in 675 Patients
Journal of Bone and Mineral Research
This study of 675 healthy adults who died prematurely due to accidents found no evidence of osteomalacia present in bone biopsies when circulating concentrations of 25(OH)D were at least30 ng/mL. They found that 22% of the adults with a circulating concentration of 25(OH) D of between 21 and 29 ng/mL had evidence of osteomalacia.