In this study, the relative risk of low 25(OH)D levels show a statistically significant 58% increase in hip fracture risk. Subgroup meta-analysis across different genders, ages, locations, study types, and follow-up durations confirmed that low serum 25(OH)D levels significantly increase hip fracture risk, especially when below 24 ng/mL.
Bones
The serum 25-hydroxyvitamin D levels and hip fracture risk: a meta-analysis of prospective cohort studies
Oncotarget
Related Studies
Bones
The Effect of Latitude on the Risk and Seasonal Variation in Hip Fracture in Sweden
Journal of Bone and Mineral Research
This study found that hip fracture incidence in Sweden increased by 3.0% per degree increase in latitude for men and by 1.9% for women. There was a marked seasonal variation of hip fracture with the highest risk in February and lower by 37.5% in men and by 23.5% women during the summer. The associations found with latitude and season are consistent with a role of vitamin D in hip fracture causation.
Bones
The Effect of Latitude on the Risk and Seasonal Variation in Hip Fracture in Sweden
Journal of Bone and Mineral Research
This study found that hip fracture incidence in Sweden increased by 3.0% per degree increase in latitude for men and by 1.9% for women. There was a marked seasonal variation of hip fracture with the highest risk in February and lower by 37.5% in men and by 23.5% women during the summer. The associations found with latitude and season are consistent with a role of vitamin D in hip fracture causation.
Bones
Bone Mineralization Defects and Vitamin D Deficiency: Histomorphometric Analysis of Iliac Crest Bone Biopsies and Circulating 25-Hydroxyvitamin D in 675 Patients
Journal of Bone and Mineral Research
This study of 675 healthy adults who died prematurely due to accidents found no evidence of osteomalacia present in bone biopsies when circulating concentrations of 25(OH)D were at least30 ng/mL. They found that 22% of the adults with a circulating concentration of 25(OH) D of between 21 and 29 ng/mL had evidence of osteomalacia.
Bones
Bone Mineralization Defects and Vitamin D Deficiency: Histomorphometric Analysis of Iliac Crest Bone Biopsies and Circulating 25-Hydroxyvitamin D in 675 Patients
Journal of Bone and Mineral Research
This study of 675 healthy adults who died prematurely due to accidents found no evidence of osteomalacia present in bone biopsies when circulating concentrations of 25(OH)D were at least30 ng/mL. They found that 22% of the adults with a circulating concentration of 25(OH) D of between 21 and 29 ng/mL had evidence of osteomalacia.
Bones
High-dose vitamin D to attenuate bone loss in patients with prostate cancer on androgen deprivation therapy: A phase 2 RCT
Cancer
This trial looking at patients receiving prostate cancer treatment found that those supplemented with 50,000 IU of vitamin D weekly had significantly reduced bone mineral density loss compared to those receiving just 600 IU of vitamin D daily. The high dose vitamin D group lost 1.5% bone mineral density at the total hip vs. 4.1% for the low-dose group and 1.7% bone mineral density at the femoral neck vs. 4.4% in the low-dose group. Stratified analyses showed that, for those with baseline vitamin D level less than 27 ng/mL, the high dose group lost 2.3% BMD at the total hip vs 7.1% for the low-dose group.
Bones
High-dose vitamin D to attenuate bone loss in patients with prostate cancer on androgen deprivation therapy: A phase 2 RCT
Cancer
This trial looking at patients receiving prostate cancer treatment found that those supplemented with 50,000 IU of vitamin D weekly had significantly reduced bone mineral density loss compared to those receiving just 600 IU of vitamin D daily. The high dose vitamin D group lost 1.5% bone mineral density at the total hip vs. 4.1% for the low-dose group and 1.7% bone mineral density at the femoral neck vs. 4.4% in the low-dose group. Stratified analyses showed that, for those with baseline vitamin D level less than 27 ng/mL, the high dose group lost 2.3% BMD at the total hip vs 7.1% for the low-dose group.