Clinical Research
The health effects of sunlight are supported by decades of research - Solius is built on that science.
See the studies - click to filter by category
Women’s health
Evidence suggests optimized vitamin D from UVB light exposure, like the Solius spectrum, may support hormone balance, reproductive and pregnancy health, strong bones, and long-term breast wellness, helping women stay resilient from early adulthood through post-menopause.
Potential benefits
Support hormonal and metabolic balance while helping maintain bone density through menopause.
Pathways that contribute to healthy pregnancy outcomes, reproductive health, and postpartum mood regulation.
Contributes to long-term protection against breast cancer.
See More
Women’s health
Evidence suggests optimized vitamin D from UVB light exposure, like the Solius spectrum, may support hormone balance, reproductive and pregnancy health, strong bones, and long-term breast wellness, helping women stay resilient from early adulthood through post-menopause.
Potential benefits
Support hormonal and metabolic balance while helping maintain bone density through menopause.
Pathways that contribute to healthy pregnancy outcomes, reproductive health, and postpartum mood regulation.
Contributes to long-term protection against breast cancer.
See More
Women’s health
Evidence suggests optimized vitamin D from UVB light exposure, like the Solius spectrum, may support hormone balance, reproductive and pregnancy health, strong bones, and long-term breast wellness, helping women stay resilient from early adulthood through post-menopause.
Potential benefits
Support hormonal and metabolic balance while helping maintain bone density through menopause.
Pathways that contribute to healthy pregnancy outcomes, reproductive health, and postpartum mood regulation.
Contributes to long-term protection against breast cancer.
See More
This study found that maternal vitamin D concentrations greater than 40 ng/mL were associated with substantial reduction in pre-term birth risk in a large, diverse population of women. Women who had a serum concentration of 25(OH)D greater or equal to 40ng/mL had a 62% lower risk of preterm births.
Maternal 25(OH)D concentrations >40 ng/mL associated with 60% lower preterm birth risk among general obstetrical patients at an urban medical center
PLOS ONE
This study found that maternal vitamin D concentrations greater than 40 ng/mL were associated with substantial reduction in pre-term birth risk in a large, diverse population of women. Women who had a serum concentration of 25(OH)D greater or equal to 40ng/mL had a 62% lower risk of preterm births.
This study found that maternal vitamin D concentrations greater than 40 ng/mL were associated with substantial reduction in pre-term birth risk in a large, diverse population of women. Women who had a serum concentration of 25(OH)D greater or equal to 40ng/mL had a 62% lower risk of preterm births.
Annals of Internal Medicine
In this study which looked at data from the Women’s Health Initiative, a 10 ng/ml decrease in vitamin D was associated with a 33% increased risk of hip fracture in multivariable models. Women with the lowest vitamin D levels had 72% increased odds of experiencing a hip fracture in comparison to women with the highest vitamin D levels.
Serum 25 HydroxyVitamin D Concentrations and the Risk of Hip Fractures: The Women's Health Initiative
Annals of Internal Medicine
In this study which looked at data from the Women’s Health Initiative, a 10 ng/ml decrease in vitamin D was associated with a 33% increased risk of hip fracture in multivariable models. Women with the lowest vitamin D levels had 72% increased odds of experiencing a hip fracture in comparison to women with the highest vitamin D levels.
Annals of Internal Medicine
In this study which looked at data from the Women’s Health Initiative, a 10 ng/ml decrease in vitamin D was associated with a 33% increased risk of hip fracture in multivariable models. Women with the lowest vitamin D levels had 72% increased odds of experiencing a hip fracture in comparison to women with the highest vitamin D levels.
This study showed that there is an increased rate of breast cancer further from the equator where there is less sunlight exposure. According to multiple regression, UVB irradiance was inversely associated with incidence rates after controlling for covariates. They also found that increasing serum 25(OH)D above 22 ng ⁄ mL was associated with incrementally lower incidence rates of breast cancer.
Relationship between Low Ultraviolet B Irradiance and Higher Breast Cancer Risk in 107 Countries
The Breast Journal
This study showed that there is an increased rate of breast cancer further from the equator where there is less sunlight exposure. According to multiple regression, UVB irradiance was inversely associated with incidence rates after controlling for covariates. They also found that increasing serum 25(OH)D above 22 ng ⁄ mL was associated with incrementally lower incidence rates of breast cancer.
This study showed that there is an increased rate of breast cancer further from the equator where there is less sunlight exposure. According to multiple regression, UVB irradiance was inversely associated with incidence rates after controlling for covariates. They also found that increasing serum 25(OH)D above 22 ng ⁄ mL was associated with incrementally lower incidence rates of breast cancer.
This review article highlights the critical role of vitamin D in maternal health, fetal skeletal development, and the achievement of optimal pregnancy outcomes. The authors report that insufficient maternal vitamin D levels are associated with an increased risk of multiple adverse outcomes, including gestational diabetes mellitus, gestational hypertension, intrauterine growth restriction, miscarriage, stillbirth, and preterm birth. These effects are attributed to vitamin D’s involvement in key biological mechanisms, including the regulation of cytokine pathways, immune system function, endocrine activity, and placental function.
Relationship between Maternal Vitamin D Levels and Adverse Outcomes
Nutrients
This review article highlights the critical role of vitamin D in maternal health, fetal skeletal development, and the achievement of optimal pregnancy outcomes. The authors report that insufficient maternal vitamin D levels are associated with an increased risk of multiple adverse outcomes, including gestational diabetes mellitus, gestational hypertension, intrauterine growth restriction, miscarriage, stillbirth, and preterm birth. These effects are attributed to vitamin D’s involvement in key biological mechanisms, including the regulation of cytokine pathways, immune system function, endocrine activity, and placental function.
This review article highlights the critical role of vitamin D in maternal health, fetal skeletal development, and the achievement of optimal pregnancy outcomes. The authors report that insufficient maternal vitamin D levels are associated with an increased risk of multiple adverse outcomes, including gestational diabetes mellitus, gestational hypertension, intrauterine growth restriction, miscarriage, stillbirth, and preterm birth. These effects are attributed to vitamin D’s involvement in key biological mechanisms, including the regulation of cytokine pathways, immune system function, endocrine activity, and placental function.
Women’s Health
Cureus
This study found that first-trimester vitamin D deficiency was significantly associated with increased risk of developing gestational diabetes mellitus (GDM) later in pregnancy. Logistic regression revealed that vitamin D deficiency resulted in a fivefold increased risk of GDM.
Women’s Health
Cureus
This study found that first-trimester vitamin D deficiency was significantly associated with increased risk of developing gestational diabetes mellitus (GDM) later in pregnancy. Logistic regression revealed that vitamin D deficiency resulted in a fivefold increased risk of GDM.
Women’s Health
European Journal of Endocrinology
In this study of 2016 healthy, recently postmenopausal women, those with vitamin D deficiency had increased risk of adverse cardiovascular outcomes including death, heart failure, myocardial infarction, and stroke. Women with low 25(OH)D levels also had significantly higher BMI and triglycerides, and lower HDL and hip–waist ratio.
Women’s Health
European Journal of Endocrinology
In this study of 2016 healthy, recently postmenopausal women, those with vitamin D deficiency had increased risk of adverse cardiovascular outcomes including death, heart failure, myocardial infarction, and stroke. Women with low 25(OH)D levels also had significantly higher BMI and triglycerides, and lower HDL and hip–waist ratio.
Women’s Health
Frontiers in Physiology
This review article describes multiple ways that vitamin D supports menopausal women’s health including the effects of vitamin D on skeletal muscle, cardiovascular disease, Genitourinary Syndrome of Menopause (GSM), cancer and emotional symptoms.
Women’s Health
Frontiers in Physiology
This review article describes multiple ways that vitamin D supports menopausal women’s health including the effects of vitamin D on skeletal muscle, cardiovascular disease, Genitourinary Syndrome of Menopause (GSM), cancer and emotional symptoms.
Women’s Health
JAMA Oncology
In this cohort study of 1666 women with breast cancer, higher serum vitamin D levels were independently associated with better outcomes, including overall survival. Compared with women with the lowest third of 25-hydroxyvitamin D levels, those with the highest third had reduced hazards of all-cause death after full adjustment, and the associations were stronger in premenopausal women.
Women’s Health
JAMA Oncology
In this cohort study of 1666 women with breast cancer, higher serum vitamin D levels were independently associated with better outcomes, including overall survival. Compared with women with the lowest third of 25-hydroxyvitamin D levels, those with the highest third had reduced hazards of all-cause death after full adjustment, and the associations were stronger in premenopausal women.
Women’s Health
Frontiers in Endocrinology
This review of 20 randomized controlled studies of women with PCOS found that vitamin D supplementation contributed to higher pregnancy and ovulation rates, and lower androgen, LH, FSH and early miscarriage rates in women with PCOS.
Women’s Health
Frontiers in Endocrinology
This review of 20 randomized controlled studies of women with PCOS found that vitamin D supplementation contributed to higher pregnancy and ovulation rates, and lower androgen, LH, FSH and early miscarriage rates in women with PCOS.
Women’s Health
The Journal of Clinical Endocrinology & Metabolism
This study found that vitamin D deficiency was associated with increased odds of primary cesarean section delivery. It was observed that women with a serum concentration of < 15 ng/mL were 50% more likely to require a cesarean section vs vaginal delivery compared to women who had a circulating concentration of 25(OH)D> 15 ng/mL. The benefit for reduced risk was observed for women who had increasing serum concentrations of 25(OH)D up to 60 ng/mL with the highest serum 25(OH)D at the lowest probability of requiring a cesarean section.
Women’s Health
The Journal of Clinical Endocrinology & Metabolism
This study found that vitamin D deficiency was associated with increased odds of primary cesarean section delivery. It was observed that women with a serum concentration of < 15 ng/mL were 50% more likely to require a cesarean section vs vaginal delivery compared to women who had a circulating concentration of 25(OH)D> 15 ng/mL. The benefit for reduced risk was observed for women who had increasing serum concentrations of 25(OH)D up to 60 ng/mL with the highest serum 25(OH)D at the lowest probability of requiring a cesarean section.
Women’s Health
The Journal of Clinical Endocrinology & Metabolism
This study found that adjusted serum 25(OH)D concentrations were lower in women who subsequently developed pre-eclampsia compared with controls. After confounder adjustment, a 20 ng/mL decline in 25(OH)D concentration doubled the risk of pre-eclampsia.
Women’s Health
The Journal of Clinical Endocrinology & Metabolism
This study found that adjusted serum 25(OH)D concentrations were lower in women who subsequently developed pre-eclampsia compared with controls. After confounder adjustment, a 20 ng/mL decline in 25(OH)D concentration doubled the risk of pre-eclampsia.
