Clinical Research
The health effects of sunlight are supported by decades of research - Solius is built on that science.
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Bone strength
Evidence suggests that UVB light, like the Solius spectrum, may increase vitamin D and improve calcium absorption to support strong, healthy bones for improved mobility and long-term independence.
Potential benefits
Natural vitamin D production to help maintain strong, healthy bones.
Support for efficient calcium absorption, critical for bone density and mobility.
Light-driven biological pathways that help preserve strength and independence through later life.
See More
Bone strength
Evidence suggests that UVB light, like the Solius spectrum, may increase vitamin D and improve calcium absorption to support strong, healthy bones for improved mobility and long-term independence.
Potential benefits
Natural vitamin D production to help maintain strong, healthy bones.
Support for efficient calcium absorption, critical for bone density and mobility.
Light-driven biological pathways that help preserve strength and independence through later life.
See More
Bone strength
Evidence suggests that UVB light, like the Solius spectrum, may increase vitamin D and improve calcium absorption to support strong, healthy bones for improved mobility and long-term independence.
Potential benefits
Natural vitamin D production to help maintain strong, healthy bones.
Support for efficient calcium absorption, critical for bone density and mobility.
Light-driven biological pathways that help preserve strength and independence through later life.
See More
Journal of Bone and Mineral Research
This study found that hip fracture incidence in Sweden increased by 3.0% per degree increase in latitude for men and by 1.9% for women. There was a marked seasonal variation of hip fracture with the highest risk in February and lower by 37.5% in men and by 23.5% women during the summer. The associations found with latitude and season are consistent with a role of vitamin D in hip fracture causation.
The Effect of Latitude on the Risk and Seasonal Variation in Hip Fracture in Sweden
Journal of Bone and Mineral Research
This study found that hip fracture incidence in Sweden increased by 3.0% per degree increase in latitude for men and by 1.9% for women. There was a marked seasonal variation of hip fracture with the highest risk in February and lower by 37.5% in men and by 23.5% women during the summer. The associations found with latitude and season are consistent with a role of vitamin D in hip fracture causation.
Journal of Bone and Mineral Research
This study found that hip fracture incidence in Sweden increased by 3.0% per degree increase in latitude for men and by 1.9% for women. There was a marked seasonal variation of hip fracture with the highest risk in February and lower by 37.5% in men and by 23.5% women during the summer. The associations found with latitude and season are consistent with a role of vitamin D in hip fracture causation.
In this study, the relative risk of low 25(OH)D levels show a statistically significant 58% increase in hip fracture risk. Subgroup meta-analysis across different genders, ages, locations, study types, and follow-up durations confirmed that low serum 25(OH)D levels significantly increase hip fracture risk, especially when below 24 ng/mL.
The serum 25-hydroxyvitamin D levels and hip fracture risk: a meta-analysis of prospective cohort studies
Oncotarget
In this study, the relative risk of low 25(OH)D levels show a statistically significant 58% increase in hip fracture risk. Subgroup meta-analysis across different genders, ages, locations, study types, and follow-up durations confirmed that low serum 25(OH)D levels significantly increase hip fracture risk, especially when below 24 ng/mL.
In this study, the relative risk of low 25(OH)D levels show a statistically significant 58% increase in hip fracture risk. Subgroup meta-analysis across different genders, ages, locations, study types, and follow-up durations confirmed that low serum 25(OH)D levels significantly increase hip fracture risk, especially when below 24 ng/mL.
This study of 675 healthy adults who died prematurely due to accidents found no evidence of osteomalacia present in bone biopsies when circulating concentrations of 25(OH)D were at least30 ng/mL. They found that 22% of the adults with a circulating concentration of 25(OH) D of between 21 and 29 ng/mL had evidence of osteomalacia.
Bone Mineralization Defects and Vitamin D Deficiency: Histomorphometric Analysis of Iliac Crest Bone Biopsies and Circulating 25-Hydroxyvitamin D in 675 Patients
Journal of Bone and Mineral Research
This study of 675 healthy adults who died prematurely due to accidents found no evidence of osteomalacia present in bone biopsies when circulating concentrations of 25(OH)D were at least30 ng/mL. They found that 22% of the adults with a circulating concentration of 25(OH) D of between 21 and 29 ng/mL had evidence of osteomalacia.
This study of 675 healthy adults who died prematurely due to accidents found no evidence of osteomalacia present in bone biopsies when circulating concentrations of 25(OH)D were at least30 ng/mL. They found that 22% of the adults with a circulating concentration of 25(OH) D of between 21 and 29 ng/mL had evidence of osteomalacia.
This trial looking at patients receiving prostate cancer treatment found that those supplemented with 50,000 IU of vitamin D weekly had significantly reduced bone mineral density loss compared to those receiving just 600 IU of vitamin D daily. The high dose vitamin D group lost 1.5% bone mineral density at the total hip vs. 4.1% for the low-dose group and 1.7% bone mineral density at the femoral neck vs. 4.4% in the low-dose group. Stratified analyses showed that, for those with baseline vitamin D level less than 27 ng/mL, the high dose group lost 2.3% BMD at the total hip vs 7.1% for the low-dose group.
High-dose vitamin D to attenuate bone loss in patients with prostate cancer on androgen deprivation therapy: A phase 2 RCT
Cancer
This trial looking at patients receiving prostate cancer treatment found that those supplemented with 50,000 IU of vitamin D weekly had significantly reduced bone mineral density loss compared to those receiving just 600 IU of vitamin D daily. The high dose vitamin D group lost 1.5% bone mineral density at the total hip vs. 4.1% for the low-dose group and 1.7% bone mineral density at the femoral neck vs. 4.4% in the low-dose group. Stratified analyses showed that, for those with baseline vitamin D level less than 27 ng/mL, the high dose group lost 2.3% BMD at the total hip vs 7.1% for the low-dose group.
This trial looking at patients receiving prostate cancer treatment found that those supplemented with 50,000 IU of vitamin D weekly had significantly reduced bone mineral density loss compared to those receiving just 600 IU of vitamin D daily. The high dose vitamin D group lost 1.5% bone mineral density at the total hip vs. 4.1% for the low-dose group and 1.7% bone mineral density at the femoral neck vs. 4.4% in the low-dose group. Stratified analyses showed that, for those with baseline vitamin D level less than 27 ng/mL, the high dose group lost 2.3% BMD at the total hip vs 7.1% for the low-dose group.
Bones
Archives of Internal Medicine
In this meta-analysis of 12 double-blinded trials no fracture reduction was observed for a received dose of 400 IU/d or less, whereas a higher received dose of 482 to 770 IU/d of supplemental vitamin D reduced nonvertebral fractures by 20% and hip fractures by 18%.
Bones
Archives of Internal Medicine
In this meta-analysis of 12 double-blinded trials no fracture reduction was observed for a received dose of 400 IU/d or less, whereas a higher received dose of 482 to 770 IU/d of supplemental vitamin D reduced nonvertebral fractures by 20% and hip fractures by 18%.
Bones
Arthritis & Rheumatism
In 228 people with primary knee osteoarthritis, those who had vitamin D levels between 16-32 ng/ml had a 7.3% higher bone mineral density than those below 15 ng/ml. Those who had a vitamin D level above 32 ng/mL had an 8.5% higher bone mineral density than those below 15 ng/ml.
Bones
Arthritis & Rheumatism
In 228 people with primary knee osteoarthritis, those who had vitamin D levels between 16-32 ng/ml had a 7.3% higher bone mineral density than those below 15 ng/ml. Those who had a vitamin D level above 32 ng/mL had an 8.5% higher bone mineral density than those below 15 ng/ml.
Bones
PLOS ONE
In a prospective cohort study of 5461 elderly participants, the estimated risk of hip fracture was twice as high in individuals with serum vitamin D concentrations below 12 ng/mL.
Bones
PLOS ONE
In a prospective cohort study of 5461 elderly participants, the estimated risk of hip fracture was twice as high in individuals with serum vitamin D concentrations below 12 ng/mL.
Bones
JAMA
A meta-analysis of randomized clinical trials found that vitamin D intakes of 700–800 IU per day reduced the relative risk of hip fracture by 26% and any nonvertebral fracture by 23% compared with just calcium or placebo. No significant benefit was observed in randomized trials with intakes of 400 IU vitamin D per day.
Bones
JAMA
A meta-analysis of randomized clinical trials found that vitamin D intakes of 700–800 IU per day reduced the relative risk of hip fracture by 26% and any nonvertebral fracture by 23% compared with just calcium or placebo. No significant benefit was observed in randomized trials with intakes of 400 IU vitamin D per day.
Bones
JAMA Network Open
A meta-analysis of six randomized control trials (49,282 participants, 5,449 fractures, 730 hip fractures) of combined supplementation with vitamin D (daily doses of 400-800 IU, yielding a median difference in vitamin D concentration of 9.2 ng/mL) and calcium (daily doses of 1000- 1200 mg) found a 6% reduced risk of any fracture and a 16% reduced risk of hip fracture.
Bones
JAMA Network Open
A meta-analysis of six randomized control trials (49,282 participants, 5,449 fractures, 730 hip fractures) of combined supplementation with vitamin D (daily doses of 400-800 IU, yielding a median difference in vitamin D concentration of 9.2 ng/mL) and calcium (daily doses of 1000- 1200 mg) found a 6% reduced risk of any fracture and a 16% reduced risk of hip fracture.
Bones
Journal of Bone and Mineral Research
This study of 1,348 women found that, compared to women with vitamin D levels less than 20 ng/mL, those with vitamin D levels between 20.4-30 ng/mL had significantly lower risk for hip fracture and fracture-related hospitalization. This adds to prior data that shows vitamin D levels below 30 ng/mL are related to increased risk of negative bone health, impaired bone structure, and increased fracture risk.
Bones
Journal of Bone and Mineral Research
This study of 1,348 women found that, compared to women with vitamin D levels less than 20 ng/mL, those with vitamin D levels between 20.4-30 ng/mL had significantly lower risk for hip fracture and fracture-related hospitalization. This adds to prior data that shows vitamin D levels below 30 ng/mL are related to increased risk of negative bone health, impaired bone structure, and increased fracture risk.
